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Impaired glucose tolerance is not associated with lipid intolerance
E Henkel1, Th Temelkova-Kurktschiev, C Koehler
1Centre of Clinical Studies-Metabolism and Endocrinology, Science and Technology Transfer GWT, Technial University Dresden, Germany.
Diabetes, Nutrition & Metabolism
|June 13, 2002
Summary
Individuals with impaired glucose tolerance (IGT) do not show lipid intolerance when fasting triglyceride levels are similar. Glucose intolerance appears to precede lipid intolerance, impacting atherosclerosis risk.
Area of Science:
- Endocrinology
- Metabolic Syndrome
- Cardiovascular Disease
Background:
- Post-prandial hypertriglyceridaemia (HTG) contributes to atherosclerosis in Type 2 diabetes.
- Impaired glucose tolerance (IGT) is linked to increased atherosclerosis risk and elevated fasting triglycerides (TG).
Purpose of the Study:
- To investigate post-prandial hypertriglyceridaemia (pp HTG) and TG-rich lipoprotein composition in individuals with IGT compared to those with normal glucose tolerance (NGT).
Main Methods:
- Study included 15 men with IGT and 27 men with NGT (fasting TG <4.6 mmol/l).
- Participants underwent oral glucose tolerance and lipid-glucose tolerance tests.
- Lipoprotein subfractions (VLDL1, VLDL2) analyzed using density gradient ultracentrifugation and compositional analysis.
Main Results:
- No significant differences in fasting or post-prandial TG, or TG Area Under Curve (AUC-TG) between IGT and NGT groups.
- A strong correlation was observed between fasting TG and AUC-TG (r=0.925; p<0.01).
- Analysis of matched pairs confirmed no significant difference in post-prandial TG between groups. No differences in VLDL subfractions or TG content were found.
Conclusions:
- IGT subjects with comparable fasting TG levels do not exhibit lipid intolerance.
- These findings suggest that glucose intolerance may precede the development of lipid intolerance.