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Related Experiment Videos

Structural changes of pulled vesicles: a Brownian dynamics simulation.

Hiroshi Noguchi1, Masako Takasu

  • 1Department of Applied Molecular Science, Institute for Molecular Science, Okazaki 444-8585, Japan. noguchi@ims.ac.jp

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|June 13, 2002
PubMed
Summary

Mechanical forces cause bilayer vesicles to change shape, forming tube-like structures and eventually undergoing fission. This process, simulated using Brownian dynamics, requires significant force to initiate vesicle deformation and splitting.

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Area of Science:

  • Biophysics
  • Materials Science
  • Computational Chemistry

Background:

  • Bilayer vesicles are fundamental structures in biological systems and nanotechnology.
  • Understanding vesicle deformation and fission is crucial for processes like membrane trafficking and drug delivery.

Purpose of the Study:

  • To investigate the structural transformations of bilayer vesicles under applied mechanical stress.
  • To elucidate the mechanism of vesicle fission induced by external forces.

Main Methods:

  • Brownian dynamics simulations were employed to model vesicle behavior.
  • Two nanoparticles were used within a vesicle, one fixed and the other subjected to a constant pulling force, mimicking optical-trapping experiments.

Main Results:

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  • Vesicle stretching into pear or tube shapes was observed.
  • Formation of a cylindrical structure between the vesicle and the pulled nanoparticle occurred.
  • Vesicle fission was induced near the moved nanoparticle, followed by shrinking of the cylindrical region.
  • A trapping force of approximately 100 pN was determined to be necessary for inducing fission.

Conclusions:

  • Mechanical forces can drive significant structural changes in bilayer vesicles, leading to fission.
  • The simulation provides a detailed mechanistic insight into force-induced vesicle dynamics.
  • The study quantifies the force threshold required for vesicle fission, relevant for biophysical applications.