Measurement of systemic oxygen uptake during low-flow anaesthesia with a standard technique vs. a novel method

We assessed agreement between measurement of systemic oxygen uptake using the Fick-derived method, and a novel method described by Biro, based on the difference in oxygen concentrations of the delivered fresh gas and the gas circulating in the circle system. Twenty-nine patients undergoing elective cardiac surgery were studied during stable haemodynamic and ventilatory conditions. Systemic oxygen uptake was measured using the two methods in each patient before and after cardiopulmonary bypass. Limits of agreement were found to be wide (-162 to 311 ml.min-1 before bypass, and -257 to 401 ml.min-1 after bypass), indicating poor agreement between the methods. No significant difference was found between the pre- and post cardiopulmonary bypass values for each method. We conclude that the Biro method, although attractive in terms of its simplicity, is an unreliable measure of systemic oxygen uptake under these conditions.