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Necrobiotic xanthogranuloma with lambda paraproteinemia: case report of successful treatment with melphalan and
P R Criado1, C Vasconcellos, J R Pegas
1Unit of Dermatology, Complexo Hospitalar Padre Bento, Guarulhos, Brazil. prcriado@directnet.com.br
Background:
Necrobiotic xanthogranuloma (NXG) is a rare non-X histiocytosis with conspicuous lesions on the periorbital skin.
Methods:
A diabetic patient presented with NXG and a previous diagnosis of necrobiosis lipoidica on the legs over a period of almost 2 years before the development of the typical lesions of NXG on the periorbital regions, back, thighs and legs. The patient was found also to have developed lambda paraproteinemia.
Results:
Treatment with melphalan and prednisone resulted in great improvement of cutaneous lesions and paraproteinemia remission.
Conclusion:
This case report details how melphalan and prednisone can be administered in the successful treatment of necrobiotic xanthogranuloma with lambda paraproteinemia.
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