Related Experiment Videos
Four pregnancies in two patients with essential thrombocythaemia--a case report
L P Koh1, K Devendra, S L Tien
1Department of Haematology, Singapore General Hospital, Outram Road, Singapore 169608. gheklp@sgh.com.sg
Introduction:
We report our experience of 4 pregnancies in 2 patients who had essential thrombocythaemia (ET).
Clinical Picture:
Two patients with ET were managed with a variety of therapeutic approaches including the use of low-dose aspirin, plateletpheresis, hydroxyurea and alpha-interferon in the course of their 4 pregnancies.
Treatment And Outcome:
One patient had 2 successful pregnancies despite having platelet counts in excess of 1000 x 10(9)/L antenatally. The second patient had an intrauterine fetal death during the third trimester of her first pregnancy but had a successful second pregnancy.
Conclusion And Clinical Implications:
Management of ET in pregnancy is still very much individualized. The impact of various treatment modalities on the pregnancy outcome remains to be proven but a favourable pregnancy outcome is possible.