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Radamycin, a novel thiopeptide produced by streptomyces sp. RSP9. II. Physico-chemical properties and structure

Julián Castro Rodríguez1, Gloria González Holgado, Ramón I Santamaría Sánchez

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The Journal of Antibiotics
|June 14, 2002
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Riboswitches

Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...