Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phagosome maturation: aging gracefully.

Otilia V Vieira1, Roberto J Botelho, Sergio Grinstein

  • 1Programme in Cell Biology, Hospital for Sick Children and Department of Biochemistry, University of Toronto, Ontario M5G 1X8, Canada.

The Biochemical Journal
|June 14, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PIKfyve influences inter-organelle contacts with lysosomes to modulate the endoplasmic reticulum.

The Journal of cell biology·2026
Same author

Beyond transport: Lysosomal solute carriers as orchestrators of immune signaling.

Molecular biology of the cell·2026
Same author

Lipid scrambling via TMEM16F mediates the formation and release of extracellular vesicles.

Molecular biology of the cell·2026
Same author

Is the Parkinson's-associated protein TMEM175 a proton channel: Yay or nay?

The Journal of cell biology·2025
Same author

Effect of ultrasound-microbubble exposure on acute myeloid leukemia cancer cell proteome.

Scientific reports·2025
Same author

Depletion of endomembrane reservoirs drives phagocytic appetite exhaustion in macrophages.

Journal of cell science·2025
Same journal

Mechanistic insights into acetylated histone recognition by the CECR2 bromodomain.

The Biochemical journal·2026
Same journal

Nanobodies against Plasmodium adhesins that block receptor engagement and malaria parasite invasion.

The Biochemical journal·2026
Same journal

Persistence without turnover: the RhoG G12E mutant highlights the role of nucleotide cycling in RhoG signaling.

The Biochemical journal·2026
Same journal

Alternative Splicing of Rice Chloroplastic CuZn Superoxide Dismutase, OsCSD2: Impact on expression and protein characteristics.

The Biochemical journal·2026
Same journal

Difference and similarity between the ubiquitous secretory pathway Ca2+-ATPases, SERCA2b, and SPCA1a.

The Biochemical journal·2026
Same journal

A molecular perspective on dimethylarginine dimethylaminohydrolases structure and function.

The Biochemical journal·2026
See all related articles

Phagocytic leucocytes engulf foreign particles into phagosomes. This review details how phagosome maturation, involving membrane fusion and fission, equips these vacuoles to eliminate pathogens and cellular debris.

Area of Science:

  • Cell biology
  • Immunology
  • Molecular biology

Background:

  • Phagocytic leucocytes are crucial for eliminating foreign particles and apoptotic bodies.
  • Phagosomes, formed by particle internalization, initially lack killing and degradation capabilities.

Purpose of the Study:

  • To review the determinants and consequences of fusion and fission reactions in phagosomal maturation.
  • To elucidate how phagosomes acquire pathogen-killing and target-degrading functions.

Main Methods:

  • Literature review of phagosomal maturation processes.
  • Analysis of membrane dynamics, including fusion and fission events.
  • Examination of molecular mechanisms driving phagosome remodeling.

Main Results:

Related Experiment Videos

  • Phagosomal maturation involves extensive membrane remodeling.
  • Fusion and fission reactions are key to acquiring functional capabilities.
  • Nascent phagosomes transform into potent antimicrobial and degradative compartments.

Conclusions:

  • Phagosomal maturation is a complex, dynamic process essential for immune defense.
  • Understanding fusion and fission mechanisms offers insights into cellular waste disposal and pathogen clearance.