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Corneal myxoma.

Gregor Wollensak1, William Richard Green, Theo Seiler

  • 1Department of Ophthalmology, University Hospital, Dresden, Germany.

Japanese Journal of Ophthalmology
|June 14, 2002
PubMed
Summary
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This study details a rare corneal myxoma, a benign tumor, in a patient with prior lens dislocation. Histology suggests origin from corneal keratocytes, likely triggered by endothelial decompensation.

Area of Science:

  • Ophthalmology
  • Surgical Pathology

Background:

  • Myxomas are rare benign tumors, typically cardiac.
  • Corneal myxomas are exceptionally rare, with only five previous cases reported in medical literature.

Observation:

  • A 46-year-old male presented with a large, whitish, elevated corneal tumor following lens luxation and endothelial decompensation.
  • The tumor occupied nearly the entire cornea, sparing only the peripheral limbus.

Findings:

  • Histology revealed a hypocellular tumor with spindle/stellate cells, myxoid stroma, and absent Bowman's layer.
  • Immunohistochemistry showed vimentin positivity, and ultrastructural analysis indicated features consistent with keratocyte origin.

Implications:

  • Ultrastructural findings support corneal keratocytes as the cellular origin of this corneal myxoma.

Related Experiment Videos

  • Chronic endothelial failure and bullous keratopathy are proposed as stimuli for tumor development.