Related Experiment Video
Updated: Sep 30, 2026
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
Published on: August 18, 2020
A volumetric MRI study of the entorhinal cortex in first episode neuroleptic-naive schizophrenia
Christian C Joyal1, Mikko P Laakso, Jari Tiihonen
1Institut Philippe Pinel de Montréal, Montreal, Canada.
Background:
Imaging studies have frequently reported volume loss of limbic structures in schizophrenia, yet there appears to be no quantitative data on entorhinal cortex volumes in patients with neuroleptic naive first-episode schizophrenia.
Methods:
The volume of the entorhinal cortices of 22 control subjects and 18 patients with neuroleptic-naïve first-episode schizophrenia were measured from magnetic resonance images (MRI) scans using recently designed anatomic criteria for MRI anatomy of the entorhinal cortex.
Results:
Smaller entorhinal volumes were found bilaterally in the schizophrenic patients. This volume loss did not correlate with items on the Positive and Negative Syndrome Scale.
Conclusions:
These data suggest early involvement of the entorhinal cortex in schizophrenia.
More Related Videos
11:03High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging
Published on: November 10, 2015
09:45Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex
Published on: March 28, 2012
