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Updated: Sep 30, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Studies on the biosynthesis of striatal-type diterpenoids and the biological activity of herical
Timm Anke1, Udo Rabe, Peter Schu
1LB Biotechnologie der Universität, Kaiserslautern, Germany. anke@rhrk.uni-kl.de
Abstract:
Feeding experiments with specifically 13C-labeled glucose disclosed that the diterpenoid part of the striatals/striatins is formed via the mevalonate pathway, whereas the pentose moiety originates either via glucuronic acid (70%) or the pentose phosphate cycle (30%). Application of radioactively labeled herical to cultures of Hericium ramosum demonstrates the pivotal role of this cyathane-xyloside in striatal biosynthesis. Herical inhibits a large spectrum of fungi and bacteria and shows cytotoxic and hemolytic properties.
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