Jove
Visualize
Contact Us

Related Experiment Videos

Damage to subcellular structures evoked by lipid peroxidation.

Mayya P Popova1, Chavdar S Popov

  • 1Department of Biology, Faculty of Agriculture, Trakia University, Stara Zagora, Bulgaria.

Zeitschrift Fur Naturforschung. C, Journal of Biosciences
|June 18, 2002
PubMed
Summary

Lipid peroxidation damages rat liver and kidney cell structures, particularly lysosomes. Thiourea effectively protected against this damage, unlike other tested scavengers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Phytochemical profiling, antimicrobial, cytotoxic and apoptotic effects of <i>Glycyrrhiza glabra</i> ethanolic extract.

Zeitschrift fur Naturforschung. C, Journal of biosciences·2026
Same journal

Rational design and biological evaluation of naturally inspired indole-oxadiazole derivatives as potent COX inhibitors.

Zeitschrift fur Naturforschung. C, Journal of biosciences·2026
Same journal

Cytotoxicity and antimicrobial activity of platinum(II) complexes based on the ligand precursor 2-phenyl-6-(1,2,3-triazol-4-yl)pyridine - influence of substituent and ancillary ligand on selectivity and activity.

Zeitschrift fur Naturforschung. C, Journal of biosciences·2026
Same journal

Structure activity relationship-guided scaffold hopping for identification of novel thiadiazole derivatives as potent SARS-CoV-2 Mpro inhibitors.

Zeitschrift fur Naturforschung. C, Journal of biosciences·2026
Same journal

Monoterpene-indole alkaloid from <i>Rinorea yaundensis</i> and antidiabetic potential of its hydrochloride.

Zeitschrift fur Naturforschung. C, Journal of biosciences·2026
Same journal

Calofrasolide A, a new pyranocoumarin from the stem bark of <i>Calophyllum fraseri</i> M.R.Hend. & Wyatt-Sm. and their antimicrobial and antibiofilm activities.

Zeitschrift fur Naturforschung. C, Journal of biosciences·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Biochemistry
  • Cell Biology
  • Toxicology

Background:

  • Lipid peroxidation (LP) is a key process in oxidative stress.
  • Understanding LP's impact on subcellular structures is crucial for cell damage research.

Purpose of the Study:

  • To investigate the effect of lipid peroxidation on rat liver and kidney subcellular structures.
  • To evaluate the protective role of free radical scavengers against LP-induced damage.

Main Methods:

  • Studied LP influence on rat liver and kidney subcellular structures under specific conditions.
  • Assessed damage in large granule fraction suspensions.
  • Tested thiobarbituric acid positive products, manitol, ethanol, and thiourea for protective effects.

Main Results:

Related Experiment Videos

  • Organelle damage occurred only when LP progressed into large granule fraction suspensions.
  • Rat liver peroxisomes were more stable than kidney peroxisomes.
  • Kidney lysosomes and neonatal liver lysosomes were more sensitive to LP than mitochondria.
  • Only thiourea demonstrated effectiveness in terminating LP and protecting membranes.

Conclusions:

  • Lipid peroxidation causes differential damage to subcellular structures based on organelle type and origin.
  • Thiourea shows significant potential as a protective agent against lipid peroxidation-induced cellular injury.