Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Size distribution effects in multiparticulate dissolution.

P V Pedersen, K F Brown

    Journal of Pharmaceutical Sciences
    |December 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Nucleotide supplementation: a randomised double-blind placebo controlled trial of IntestAidIB in people with Irritable Bowel Syndrome [ISRCTN67764449].

    Nutrition journal·2006
    Same author

    Validation of methods to study the distribution and protein binding of tacrolimus in human blood.

    Journal of pharmacological and toxicological methods·2002
    Same author

    Influence of respiratory spacer devices on aerodynamic particle size distribution and fine particle mass of beclomethasone from metered-dose inhalers.

    Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2002
    Same author

    High-performance liquid chromatographic analysis of mometasone furoate and its degradation products: application to in vitro degradation studies.

    Journal of pharmaceutical and biomedical analysis·2001
    Same author

    In-vitro characterisation of metered dose inhaler versus dry powder inhaler glucocorticoid products: influence of inspiratory flow rates.

    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques·2001
    Same author

    Metabolism kinetics of beclomethasone propionate esters in human lung homogenates.

    Pharmaceutical research·2000

    Particle size distribution significantly impacts drug dissolution modeling. Accurate particle-size analysis is crucial to prevent misinterpreting dissolution data and ensure reliable model evaluation.

    Area of Science:

    • Pharmaceutical Sciences
    • Physical Chemistry

    Background:

    • Evaluating single-particle dissolution models using multiparticulate data is challenging due to particle-size distribution effects.
    • Non-monodispersed particles can lead to apparent linearity with incorrect models, complicating analysis.

    Purpose of the Study:

    • To investigate the impact of particle-size distribution on the evaluation of dissolution models.
    • To propose methods for accurately assessing dissolution kinetics and preventing misinterpretation of data.

    Main Methods:

    • Utilized simulated data from log-normal particle size distributions.
    • Calculated changes in particle-size distribution during dissolution.
    • Introduced and applied the concept of "time scaling" to transform dissolution profiles.

    Related Experiment Videos

    Main Results:

    • Demonstrated that incorrect models can yield linear results with log-normal powders.
    • Particle-size analysis is essential for accurate model evaluation.
    • Time scaling effectively reduces computational errors and allows for interference-free evaluation of the distribution effect.

    Conclusions:

    • Particle-size distribution significantly influences the interpretation of dissolution data.
    • Accurate particle-size analysis and methods like time scaling are vital for reliable dissolution model assessment.
    • The proposed methods can help distinguish between different dissolution models and prevent misinterpretation.