GLC determination of underivatized carbamazepine in whole blood

This report describes a rapid GLC assay for carbamazepine in blood. Carbamazepine is chromatographed directly using phenyl methyl silicone gum as the stationary phase. The calibration curve is linear up to 50 mug/ml, with a lower limit of sensitivity of 1 mug/ml. Other anticonvulsants may be measured simultaneously, and the procedure works equally well with plasma or blood.