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Description of a Swine Infant Model of Volume-Controlled Hemorrhagic Shock

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Preventing postpartum hemorrhage in low-resource settings.

M L McCormick¹, H C G Sanghvi, B Kinzie

¹JHPIEGO Corporation, Baltimore, MD, USA.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics

|June 18, 2002

Summary

Active management of the third stage of labor, particularly with uterotonic drugs like oxytocin, effectively prevents postpartum hemorrhage (PPH). This approach is crucial for reducing maternal mortality globally, especially in developing countries.

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Published on: September 12, 2025

Area of Science:

Obstetrics and Gynecology
Maternal Health
Evidence-Based Medicine

Background:

Postpartum hemorrhage (PPH) is the leading cause of maternal mortality worldwide.
Effective prevention strategies are critical for improving maternal outcomes.

Purpose of the Study:

To identify the most effective methods for preventing postpartum hemorrhage (PPH).
To review the scientific literature for evidence-based PPH prevention strategies.

Main Methods:

Systematic review of published randomized controlled trials.
Inclusion of relevant review articles to synthesize existing evidence.

Main Results:

Active management of the third stage of labor significantly reduces PPH risk from uterine atony.
Uterotonic drugs, especially oxytocin, are key to preventing PPH without increasing complications.
Misoprostol offers an alternative for PPH prevention where parenteral medications are inaccessible.

Conclusions:

Active management of the third stage of labor is recommended for PPH prevention.
Expansion of these practices is particularly vital in developing countries.
Evidence supports the use of uterotonics to combat uterine atony and reduce maternal mortality.