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Related Experiment Videos

Perinatal corticosteroids and the developing lung.

Alan T Gibson1

  • 1North Trent Neonatal Intensive Care Unit, Jessop Wing, Sheffield Teaching Hospitals NHS Trust, Tree Root Walk, Sheffield S10 2SF, UK. A.T.Gibson@Sheffield.ac.uk

Paediatric Respiratory Reviews
|June 18, 2002
PubMed
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Antenatal corticosteroids reduce infant mortality and respiratory distress. However, postnatal corticosteroid use for chronic lung disease in premature infants has questionable benefits and significant long-term risks.

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Pharmacology

Background:

  • Premature infants often develop respiratory disease and chronic lung disease, leading to high mortality and morbidity.
  • Antenatal corticosteroid administration to mothers significantly reduces infant mortality, respiratory distress syndrome, and intracranial hemorrhage.
  • Postnatal corticosteroids have been a long-standing treatment for chronic lung disease in premature infants.

Purpose of the Study:

  • To evaluate the current understanding of corticosteroid use in premature infants.
  • To critically assess the benefits versus the risks of postnatal corticosteroid therapy.
  • To examine recent evidence questioning the established cost-benefit ratio of this treatment.

Main Methods:

  • Review of recent meta-analyses on postnatal corticosteroid efficacy.

Related Experiment Videos

  • Analysis of data on the side-effects of corticosteroid treatment.
  • Evaluation of long-term adverse effects reported in recent studies.

    • Main Results:

    • Recent meta-analyses indicate limited benefits of postnatal corticosteroids for chronic lung disease.
    • Corticosteroid treatment is associated with various side-effects.
    • Emerging evidence highlights significant and permanent long-term adverse effects.

    Conclusions:

    • The traditional assumption that the benefits of postnatal corticosteroids outweigh the risks is now questionable.
    • Further research is needed to re-evaluate the risk-benefit profile of long-term corticosteroid use in premature infants.
    • Clinical practice regarding postnatal corticosteroids requires re-evaluation in light of new evidence.