Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

SALL1 expression in the human pituitary-adrenal/gonadal axis.

Y Ma1, L Chai, S C Cortez

  • 1Department of Pathology, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA.

The Journal of Endocrinology
|June 18, 2002
PubMed
Summary

The SALL1 gene, linked to Townes-Brocks Syndrome, is expressed in key reproductive endocrine tissues. This suggests SALL1 plays a crucial role in the pituitary-adrenal-gonadal axis during reproduction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recipe optimization and SRF test of Cu-compatible Nb[Formula: see text]Sn films by DC magnetron sputtering from a stoichiometric target.

Scientific reports·2026
Same author

Abstracts of the 26th International Workshop on Clinical Pharmacology of HIV, Hepatitis and other Antiviral Drugs 2025, 3-4 September 2025, Amsterdam, the Netherlands.

British journal of clinical pharmacology·2025
Same author

Use of zinc deposited in deciduous teeth as a retrospective measurement of dietary zinc exposure during early development.

Frontiers in oral health·2023
Same author

Long-term clinical, virological and immunological outcomes following planned treatment interruption in HIV-infected children.

HIV medicine·2020
Same author

Lessons for test and treat in an antiretroviral programme after decentralisation in Uganda: a retrospective analysis of outcomes in public healthcare facilities within the Lablite project.

International health·2019
Same author

GooD4Mum: A general practice-based quality improvement collaborative for diabetes prevention in women with previous gestational diabetes.

Primary care diabetes·2018

Area of Science:

  • Developmental Biology
  • Endocrinology
  • Genetics

Background:

  • SALL1 gene identified via homology to Drosophila Sal homeotic gene.
  • SALL1 is associated with Townes-Brocks Syndrome (TBS), a disorder causing multiorgan dysgenesis.
  • Previous studies linked SALL1 to reproductive tissues, but its broader role was unclear.

Purpose of the Study:

  • To investigate SALL1 gene expression and protein localization in reproductive endocrine tissues.
  • To explore the potential role of SALL1 in the reproductive endocrine axis.
  • To correlate SALL1 expression patterns with TBS phenotypes.

Main Methods:

  • Evaluated SALL1 mRNA production and p140 protein localization.
  • Utilized immunohistochemistry in adult and fetal tissues.

Related Experiment Videos

  • Examined SALL1 expression in pituitary, adrenal cortex, placenta, gonads, and trophoblast tumors.

    • Main Results:

    • SALL1 protein (p140) localized to the adenohypophysis, co-localizing with GH, LH, and FSH producing cells.
    • Detected SALL1 expression in fetal and adult adrenal cortex and placental trophoblastic cells.
    • Confirmed SALL1 expression in Leydig cells, Sertoli cells, granulosa cells, and elevated in trophoblast tumors.

    Conclusions:

    • SALL1 is expressed across multiple levels of the reproductive endocrine axis, including the pituitary, adrenal glands, and gonads.
    • The expression pattern suggests SALL1 is involved in reproductive endocrine functions.
    • SALL1's role in the pituitary-adrenal/gonadal axis warrants further investigation, especially concerning TBS.