Puberty in children with cancer
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Updated: Sep 30, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
Published on: October 14, 2016
Stephen M Shalet1, Bernadette M D Brennan
1Department of Endocrinology, Christie Hospital NHS Trust, Manchester, UK. stephen.m.shalet@man.ac.uk
Abstract:
Cancer may impinge on puberty either directly through a mass lesion effect on the reproductive axis or indirectly through hormones secreted by tumours, for example human chorionic gonadotrophin, or weight loss, or the actual presence of a chronic disease process per se. The more frequent pubertal problems faced by children with cancer are due to the impact of treatment either on the central nervous system, the hypothalamic-pituitary axis or the gonad; in this review, we concentrate on these complications and their potential management.
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