Related Experiment Video
Updated: May 1, 2026

Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
Published on: June 27, 2015
The renal tubular handling of aldosterone and its acid-labile conjugate
Abstract:
Stop-flow studies using infusions of aldosterone-(3)H or its (3)H acid-labile conjugate were done on five rhesus monkeys. The aldosterone-(3)H urine-to-plasma (U/P) ratio decreased in the same distal urine samples as sodium. The (3)H acid-labile conjugate U/P-to-inulin U/P ratio increased in the more proximal samples either with conjugate formed endogenously during aldosterone-(3)H infusions or with labeled conjugate infused alone. Aldosterone reabsorption occurred at a distal site in the renal tubule, and secretion of its acid-labile conjugate occurred at a proximal site.
Related Concept Videos
Drug Elimination by Renal Route: Tubular Reabsorption
Drug Elimination by Renal Route: Tubular Secretion
Renal Regulation of Acid-Base Balance
In the kidneys, cells within the proximal convoluted tubules (PCT) and the collecting ducts secrete hydrogen ions (H+) into the tubular fluid. Specifically, in the PCT, Na+/H+ antiporters secrete H+ while reabsorbing Na+.
However, the intercalated cells in...
Renal Drug Excretion: Tubular Reabsorption
Renal Drug Excretion: Tubular Secretion
Physiology of the Genitourinary System II: Tubular Reabsorption and Secretion

