Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cellular oscillators in animal segmentation.

Johannes Jaeger1, Brian C Goodwin

  • 1Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, 11794-5222, USA. yoginho@usa.net

In Silico Biology
|June 18, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Naturalizing relevance realization: why agency and cognition are fundamentally not computational.

Frontiers in psychology·2024
Same author

Assembly Theory: What It Does and What It Does Not Do.

Journal of molecular evolution·2024
Same author

An epistemology for democratic citizen science.

Royal Society open science·2023
Same author

The flow of substance: a reply to Horsting & Hartjes.

EMBO reports·2022
Same author

The origin of RNA interference: Adaptive or neutral evolution?

PLoS biology·2022
Same author

Homology of process: developmental dynamics in comparative biology.

Interface focus·2021
Same journal

Regulatory Effects of Cooperativity and Signal Profile on Adaptive Dynamics in Incoherent Feedforward Loop Networks.

In silico biology·2025
Same journal

scAN1.0: A reproducible and standardized pipeline for processing 10X single cell RNAseq data.

In silico biology·2023
Same journal

Modelling speciation: Problems and implications.

In silico biology·2022
Same journal

Where Do CABs Exist? Verification of a specific region containing concave Actin Bundles (CABs) in a 3-Dimensional confocal image.

In silico biology·2022
Same journal

Network analysis of host-pathogen protein interactions in microbe induced cardiovascular diseases.

In silico biology·2022
Same journal

Multiscale modeling of tumor response to vascular endothelial growth factor (VEGF) inhibitor.

In silico biology·2022
See all related articles

We developed a cellular oscillator model for pattern formation in developing organisms, applicable even without detailed molecular data. This model explains periodic gene expression and segment formation across diverse species.

Area of Science:

  • Developmental Biology
  • Systems Biology
  • Biophysics

Background:

  • Kinetic modeling of developmental dynamics necessitates comprehensive genetic and metabolic network data, often unavailable for many processes.
  • Existing models struggle with systems lacking detailed molecular information.

Purpose of the Study:

  • To present a coarse-grained, phenomenological model for periodic pattern formation in multicellular organisms.
  • To provide a model applicable to systems with limited molecular data, based on cellular oscillators (CO).

Main Methods:

  • Developed a phenomenological model of periodic pattern formation using cellular oscillators.
  • Simulated the model's application to vertebrate somitogenesis.
  • Analyzed the model's ability to reproduce gene expression patterns and segment formation dynamics.

Related Experiment Videos

Main Results:

  • The cellular oscillator model successfully reproduces periodic gene expression patterns in vertebrate somitogenesis.
  • Model variations can generate different somite lengths by altering oscillation periods.
  • The model suggests potential underlying dynamical principles for sequential segmentation across diverse animal phyla.

Conclusions:

  • The cellular oscillator model offers a framework for understanding developmental pattern formation in data-limited systems.
  • This dynamical principle of sequential segmentation may be conserved across the animal kingdom, despite differing gene involvement.
  • The model provides insights into the fundamental mechanisms driving periodic pattern generation during development.