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New molecular mediators in tumor angiogenesis
W.-D. Beecken1, W. Kramer, D. Jonas
1Uniklinikum Frankfurt/Main, Klinik für Urologie und Kinderurologie, Theodor-Stern-Kai 7, 60590 Frankfurt/Main, Germany. Beecken@em.uni-frankfurt.de
Journal of Cellular and Molecular Medicine
|June 18, 2002
Summary
Tumor growth relies on angiogenesis, the formation of new blood vessels. This review explores new mediators influencing this process, crucial for cancer progression.
Area of Science:
- Oncology
- Vascular Biology
Background:
- Tumor growth beyond 1-2 mm³ necessitates angiogenesis.
- Angiogenesis is regulated by a balance of endothelial cell stimulators and inhibitors.
- Tumor progression correlates with serum angiogenic mediator concentrations and tumor vascular density.
Purpose of the Study:
- To review the mechanisms driving tumor angiogenesis.
- To discuss newly identified mediators of endothelial cell growth and inhibition.
Main Methods:
- Literature review of mechanisms and mediators of angiogenesis.
- Discussion of recent findings on endothelial cell growth factors and inhibitors.
Main Results:
- Angiogenesis is a critical factor in tumor growth and metastasis.
- Several new mediators, including angiopoietins, midkine, pleiotropin, leptin, and maspin, have been identified.
- The balance of angiogenic mediators is often disrupted in tumors.
Conclusions:
- Understanding tumor angiogenesis and its mediators is vital for developing anti-cancer therapies.
- Targeting specific angiogenic factors offers potential therapeutic strategies for cancer treatment.