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4,4-Disubstituted cyclohexylamine NK(1) receptor antagonists II
Laura C Cooper1, Emma J Carlson, Jose L Castro
1Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK. laura_cooper@merck.com
Bioorganic & Medicinal Chemistry Letters
|June 18, 2002
Abstract:
A series of novel 4,4-disubstituted cyclohexylamines as NK(1) receptor antagonists is described: modifications to the amine moiety retain NK(1) receptor binding affinity whilst disrupting I(Kr) affinity.