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Apolipoproteins and aging: emerging mechanisms.

Jonathan D Smith1

  • 1Lab. Biochem. Gen. & Metabolism, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA. smithj@rockefeller.edu

Ageing Research Reviews
|June 18, 2002
PubMed
Summary

Successful aging requires survival and good health. Apolipoprotein E (apoE) influences longevity, with the E4 variant increasing risks for heart disease, stroke, and Alzheimer

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Area of Science:

  • Gerontology and Molecular Biology
  • Biochemistry of Aging
  • Genetics of Longevity

Background:

  • Successful aging involves both survival and maintaining cognitive and physical health.
  • Apolipoproteins, particularly apolipoprotein E (apoE), play a significant role in aging processes.
  • Understanding apoE's function is crucial for developing strategies to promote healthy longevity.

Purpose of the Study:

  • To discuss the impact of apolipoprotein E (apoE) on longevity and successful aging.
  • To examine the role of different apoE isoforms in healthspan and lifespan.
  • To explore potential mechanisms linking apoE to aging-related diseases.

Main Methods:

  • Literature review and synthesis of existing research on apolipoprotein E and aging.
  • Analysis of studies investigating the association between apoE variants and age-related diseases.
  • Discussion of biochemical and genetic pathways influenced by apoE.

Main Results:

  • Apolipoprotein E (apoE) significantly affects longevity and successful aging.
  • The apoE E4 variant is linked to an elevated risk of cardiovascular disease, stroke, and Alzheimer's disease.
  • Specific isoforms of apoE differentially impact healthspan and susceptibility to age-related pathologies.

Conclusions:

  • Apolipoprotein E is a key determinant of successful aging.
  • The apoE E4 isoform presents a significant risk factor for major age-related diseases.
  • Further research into apoE's mechanisms can inform interventions for promoting healthy aging.

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