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Chromatin as a eukaryotic template of genetic information
1Institut de Génétique Humaine-CNRS, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France. Giacomo.Cavalli@igh.cnrs.fr
Current Opinion in Cell Biology
|June 18, 2002
Abstract:
In eukaryotes, chromatin is essential for heredity. Chromatin architecture is sometimes "epistatic" over the DNA and imparts a different heritable state to the same DNA sequence or the same functional state to unrelated DNA sequences. This has been documented recently in a wide variety of studies focused on regulation of the yeast mating type, the function of Polycomb and trithorax group proteins, the specification of eukaryotic centromeres and neocentromeres, and genomic imprinting.