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Updated: Jun 26, 2026

Imaging Centrosomes in Fly Testes
Published on: September 21, 2013
The centrosome cycle
1Department of Cell Biology, Max-Planck-Institute for Biochemistry, D-82152 Martinsried, Germany.
Abstract:
The centrosome is the major microtubule-organizing center of animal cells. It influences cell shape and polarity and directs the formation of the bipolar mitotic spindle. Numerical and structural centrosome aberrations have been implicated in disease, notably cancer. In dividing cells, centrosomes need to be duplicated and segregated in synchrony with chromosomes. This centrosome cycle requires a series of structural and functional transitions that are regulated by both phosphorylation and proteolysis. Here we summarize recent information on the regulation of the centrosome cycle and its coordination with the chromosomal cell cycle.
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