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Related Experiment Videos

Adverse event associated with methionine loading test: a case report.

E M Cottington1, Christian LaMantia, Sally P Stabler

  • 1Case Western Reserve University, Cleveland, Ohio, USA.

Arteriosclerosis, Thrombosis, and Vascular Biology
|June 18, 2002
PubMed
Summary

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A study on methionine and Alzheimer's disease reported a subject's death following an oral methionine load. Extremely high methionine levels, likely due to an overdose, suggest potential severe cerebral effects.

Area of Science:

  • Biochemistry
  • Neuroscience
  • Toxicology

Background:

  • Investigating the link between homocysteine and Alzheimer's disease.
  • Utilizing oral methionine loading tests to study metabolite concentrations.

Observation:

  • A control subject experienced an unexpected death post-methionine administration.
  • Postload plasma methionine levels were exceptionally high, exceeding previously reported human values.
  • Preload metabolite profiles excluded known genetic predispositions to hypermethioninemia.

Findings:

  • The most probable cause was a significant overdose of methionine.
  • Extremely elevated methionine concentrations may induce severe cerebral effects.

Implications:

Related Experiment Videos

  • Caution is advised when increasing methionine dosage in loading tests.
  • Further research is needed to understand the neurotoxic potential of extreme methionine levels.
  • Re-evaluation of methionine loading test protocols is recommended to ensure subject safety.