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Regional left ventricular function during transient coronary occlusion: relation with coronary collateral flow.
1Cardiology, Swiss Cardiovascular Centre Bern, University Hospital, Bern, Switzerland. christian.seiler.cardio@insel.ch
Heart (British Cardiac Society)
|June 18, 2002
Summary
Regional left ventricular (LV) function during coronary artery angioplasty is directly linked to collateral blood flow. Adequate collateral flow preserves LV function during brief occlusions, crucial for preventing ischemia.
Area of Science:
- Cardiology
- Cardiovascular Physiology
- Interventional Cardiology
Background:
- Assessing regional left ventricular (LV) function during percutaneous transluminal coronary angioplasty (PTCA) is vital.
- Collateral circulation plays a key role in myocardial protection during coronary occlusion.
Purpose of the Study:
- To investigate the relationship between regional LV function and collateral blood flow during PTCA.
- To test if collateral flow amount predicts LV functional changes during temporary coronary artery occlusion.
Main Methods:
- Prospective study in 50 patients with coronary artery disease undergoing PTCA.
- Regional systolic and diastolic LV function assessed by tissue Doppler ultrasound (TD) during 60-second occlusions.
- Collateral flow index (CFI) calculated using pressure-derived measurements.
Main Results:
- Significant differences in TD-derived LV function parameters between patients with sufficient and insufficient collateral flow.
- Direct correlations found between CFI and measures of regional systolic and diastolic function.
- LV systolic excursion velocity and diastolic function correlated with collateral flow.
Conclusions:
- Regional LV systolic and diastolic function during brief coronary occlusions are directly related to collateral flow.
- Collateral circulation is a key determinant of myocardial function preservation during PTCA.