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Related Experiment Videos

Rhythm generation in monkey motor cortex explored using pyramidal tract stimulation.

A Jackson1, R L Spinks, T C B Freeman

  • 1Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, UK.

The Journal of Physiology
|June 18, 2002
PubMed
Summary
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Pyramidal tract (PT) stimulation resets beta oscillations in macaque motor cortex. This finding suggests PT neurons directly influence motor rhythms and muscle activity, potentially via inhibitory feedback.

Area of Science:

  • Neuroscience
  • Motor Control
  • Computational Neuroscience

Background:

  • Beta oscillations (15-30 Hz) are prominent in the motor cortex during motor tasks.
  • The precise mechanisms generating these oscillations and their relation to descending motor commands are not fully understood.

Purpose of the Study:

  • To investigate if stimulating the pyramidal tract (PT) can reset beta oscillations in the macaque motor cortex.
  • To explore the role of pyramidal tract neurons (PTNs) in generating motor cortex rhythms and corticomuscular coherence.

Main Methods:

  • Recorded local field potentials (LFPs) and single-unit activity from macaque monkeys performing a precision grip task.
  • Delivered single PT stimuli during the task and analyzed stimulus-triggered LFP and electromyography (EMG) responses.

Related Experiment Videos

  • Examined single-unit firing patterns of PTNs and other neurons following stimulation.

    • Main Results:

    • PT stimulation induced a phase-locked oscillatory response in the LFP, resetting ongoing beta rhythms (15-30 Hz).
    • A lower frequency 10 Hz component was also observed in the LFP response.
    • EMG activity showed the higher frequency (15-30 Hz) only at stronger stimulus intensities.
    • Stimulation during movement yielded a reduced oscillatory response.
    • Single-unit analysis confirmed PT stimulation reset periodic neuronal activity, showing suppression and facilitation cycles.

    Conclusions:

    • PTN activity directly influences the generation of 15-30 Hz beta rhythms in the motor cortex.
    • PTNs facilitate EMG activity, contributing to corticomuscular coherence at beta frequencies.
    • Inhibitory feedback mechanisms may play a crucial role in generating these motor cortical oscillations.