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Updated: Jul 15, 2026
High-resolution Functional Magnetic Resonance Imaging Methods for Human Midbrain
Published on: May 10, 2012
Histopathologic correlation of high-resolution magnetic resonance imaging of human cervical tissue samples at 3
Bence Csapó1, József Széles, Thomas H Helbich
1NMR-group, Department of Medical Physics, Department of Gynecology and Obstetrics, University of Vienna, Austria.
Rationale And Objectives:
High-resolution magnetic resonance (HR-MR) images of human cervical tissue samples were correlated with low magnification histology to investigate the MR presentation of normal and pathologic anatomic structures in cervical tissue samples at 3T.
Methods:
Tissue samples were obtained from five large loop excision of the transformation zone (LLETZ) cone biopsies and one surgical specimen. HR-MR images (3D-Spin Echo sequence: TR/TE: 1500/60 milliseconds, voxel size of 117 x 208 x 234 microm) and low magnification (5x) histology sections were acquired in the same anatomical planes and correlated.
Results:
In vitro HR-MR imaging of cervical tissue samples correlated well with low magnification microscopic histology, demonstrating normal anatomy (epithelium and its mucus layer, connective tissue of the stroma, glands, blood vessels). In vitro HR-MR imaging adds information about tumor content and margins.
Conclusions:
High resolution MR imaging of cervical tissue samples assists in the identification of both normal structures and pathologic changes.
