[Relationship between lipid and carbohydrate metabolism and hyperinsulinemia in coronary arteriosclerosis]

The disorders in the carbohydrates metabolism were studied along with the level of insulinemia in patients with coronary atherosclerosis, and the interrelationship between the pathological shifts in the lipid and carbohydrates metabolism were clarified. The study was conducted in 45 persons: 31 patients with coronary atherosclerosis and 14 normals. The indices of the lipid (cholestrol, triglycerides, NEFA, lipoproteids) and carbohydrates metabolism (blood sugar immunoreactive insulin) were analysed on an empty stomach and after glucose provocation. Twenty of the 31 patients demonstrated hyperinsulinemia, 25--an altered tolerance of carbohydrates. The authors believe that in atherosclerosis hyperinsulinemia develops against the background of pre-existing disorders in the lipid metabolism, and correlates with the degree of the increase in atherogenic lipoproteids.