[Stimulation of protein synthesis in damaged cardiac muscle with RNA preparations]

Local injuries of the myocardium in rats induced by means of diathermocoagulation, as judged by the inclusion of C14-labelled aminoacids, stimulate the reparative biosynthesis of proteins in the injured and intact zones of the myocardium. Intraperitoneal administrations of a polymer RNA preparation from the cattle liver (6 mg/100 g of body weight) enhance the biosynthesis of proteins in the injured and intact zones of the myocardium 1.5--2--fold. The enzymatic hydrolyzate of RNA produces a less distinct stimulating effect. The authors believe that the RNA preparations may find their place in clinical stimulation of the reparative processes in the injured myocardium.