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[Thyroid function tests in viral chronic hepatitis].

M Novis1, M Vaisman, H S Coelho

  • 1Serviço de Gastroenterologia, Hospital Universitário Clementino Fraga Filho, Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, FM-UFRJ.

Arquivos De Gastroenterologia
|June 19, 2002
PubMed
Summary
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Thyroid hormone levels, specifically triiodothyronine (T3), decrease as liver disease worsens. Elevated reverse triiodothyronine (rT3) and the rT3/T3 index correlate with advanced hepatic dysfunction in patients with chronic hepatitis and cirrhosis.

Area of Science:

  • Endocrinology
  • Hepatology
  • Internal Medicine

Context:

  • Chronic active hepatitis and postnecrotic cirrhosis significantly impair liver function.
  • Liver dysfunction affects various hormonal systems, including thyroid function.
  • Assessing thyroid profiles can offer insights into disease severity and prognosis.

Purpose:

  • To determine the thyroid hormonal profile in patients with chronic hepatitis and cirrhosis.
  • To evaluate the prognostic value of thyroid tests in relation to disease progression and mortality.
  • To compare thyroid function test results with the Child-Pugh classification system.

Summary:

  • Serum levels of total triiodothyronine (T3) significantly decreased with advancing liver disease severity (Chronic Active Hepatitis to Child-Pugh C cirrhosis).

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  • Patients with advanced cirrhosis (Child-Pugh C) exhibited lower thyroxine (T4) and free T4 (FT4) levels, alongside elevated thyroid-stimulating hormone (TSH), reverse T3 (rT3), and rT3/T3 index.
  • The thyrotropin-releasing hormone (TRH) test results were largely normal across patient groups.

    • Impact:

    • Thyroid hormone profiles, particularly T3 and rT3 levels, demonstrate a strong correlation with the degree of hepatic dysfunction.
    • These findings suggest that thyroid hormone measurements can serve as a valuable indicator of liver disease severity.
    • The study highlights the utility of thyroid function tests in complementing the Child-Pugh classification for assessing patients with chronic liver disease.