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[Intestinal absorption of D-xylose in children infected with the human immunodeficiency virus]

N M Perin1, M M Pires, S M Nassar

  • 1Universidade Federal de Santa Catarina, Serviço de Gastroenterologia Pediátrica, Hospital Infantil Joana de Gusmão. nperin@fitnet.com.br

Arquivos De Gastroenterologia
|June 19, 2002
PubMed

Insights

Intestinal malabsorption is uncommon in HIV-infected children. When present, it is linked to Cryptosporidium infection, not other factors like diarrhea or immune status.

Area of Science:

  • Pediatric Infectious Diseases
  • Gastroenterology
  • Clinical Immunology

Context:

  • Human Immunodeficiency Virus (HIV) infection impacts children globally.
  • Gastrointestinal complications are common in pediatric HIV.
  • Understanding intestinal dysfunction is crucial for managing nutritional status and growth.

Purpose:

  • To assess intestinal absorption using serum D-xylose levels in HIV-infected children.
  • To determine the relationship between malabsorption and diarrhea, nutritional status, immune dysfunction, and enteric pathogens.
  • To specifically investigate the role of Cryptosporidium in intestinal dysfunction.

Summary:

  • Serum D-xylose absorption was evaluated in 104 HIV-infected children aged 14 months to 14 years.
  • Altered D-xylose absorption was found in 7.7% of children; Cryptosporidium was detected in 31.73%.
  • Multiple correspondence analysis indicated an association between malabsorption and Cryptosporidium, but not with diarrhea, nutritional status, or immune dysfunction.

Impact:

  • Intestinal malabsorption is infrequent in this pediatric HIV population.
  • Cryptosporidium appears to be a significant factor in intestinal dysfunction among HIV-infected children.
  • Findings suggest targeted interventions for Cryptosporidium may improve gut health in these children.
Abstract

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