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Updated: Aug 12, 2026

Thermodynamics of Membrane Protein Folding Measured by Fluorescence Spectroscopy
Published on: April 28, 2011
[Sensitivity of the folding pathway to the details of amino acid sequence]
1Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia. ogalzit@vega.protres.ru
Abstract:
Experimental data on the structure of transition state demonstrate that the proteins with the same topology as a rule have similar folding nuclei (the structured formed part of the transition state). In this review we discuss the experimental works which show that the position of folding nuclei is different among proteins with the same topology. These facts underline that the folding pathway is sensitive to the details of amino-acid sequence.
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