[Evidence-based guideline for the diagnosis and treatment of ulcerative colitis]

The therapy of ulcerative colitis is still not causal but is directed unspecifically at mucosal inflammation. The treatment of the uncomplicated remitting course is tailored to the activity and location of the disease. In the case of mild to moderate activity aminosalicylates are recommended, in the absence of a response systemic steroids are the treatment of choice. However, when administered locally, aminosalicylates have proven superior to steroids. Chronic active disease should be treated with azathioprine. A steroid-refractory course often responds to ciclosporine or tacrolimus: A course refractory to conservative measures is an indication for a proctocolectomy with ileoanal anastomosis.