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Updated: Sep 30, 2026
Microsatellite DNA Genotyping and Flow Cytometry Ploidy Analyses of Formalin-fixed Paraffin-embedded Hydatidiform Molar Tissues
Published on: October 20, 2019
Do nontriploid partial hydatidiform moles exist? A histologic and flow cytometric reevaluation of nontriploid
David R Genest1, Robert E Ruiz, Stana Weremowicz
1Department of Obstetrics and Gynecology, New England Trophoblastic Disease Center, Brigham and Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA. dgenest@partners.org
Objective:
To study whether nontriploid partial hydatidiform moles truly exist.
Study Design:
We conducted a reevaluation of pathology and ploidy in 19 putative nontriploid partial hydatidiform moles using standardized histologic diagnostic criteria and repeat flow cytometric testing by the Hedley technique.
Results:
On review of the 19 moles, 53% (10/19) were diploid nonpartial moles (initially pathologically misclassified), and 37% (7/19) were triploid partial moles (initial ploidy misclassifications). One additional case (5%) was a diploid early complete mole (initially pathologically misclassified).
Conclusion:
Nontriploid partial moles probably do not exist: careful reevaluation of putative specimens will probably uncover pathologic or ploid errors in almost all cases.
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