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Prothrombin G20210A mutation is not associated with recurrent miscarriages.

Chua Boon Ghee1, Robert F Burrows

  • 1Department of Obstetrics and Gynaecology, Monash University, Victoria, Australia.

The Australian & New Zealand Journal of Obstetrics & Gynaecology
|June 19, 2002
PubMed
Summary

This study found no evidence linking the prothrombin G20210A mutation to recurrent miscarriages. Further research is needed to clarify any potential association with pregnancy loss.

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Area of Science:

  • Reproductive Medicine
  • Genetics
  • Thrombophilia

Background:

  • Recurrent miscarriage affects a significant number of women.
  • The prothrombin G20210A mutation is a known risk factor for venous thromboembolism.
  • Its role in recurrent pregnancy loss remains controversial.

Purpose of the Study:

  • To evaluate the association between the prothrombin G20210A mutation and recurrent miscarriages.
  • To synthesize existing evidence through a meta-analysis.

Main Methods:

  • A comprehensive literature search was conducted in Medline from 1966 to December 2000.
  • Articles meeting predefined inclusion criteria were systematically reviewed.
  • A meta-analysis was performed on six case-controlled trials involving 323 women.

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Main Results:

  • The odds ratio for heterozygous prothrombin mutation was 1.9 (95% CI 0.98-4.14).
  • The odds ratio for homozygous prothrombin mutation was 3.76 (95% CI 0.75-18.77).
  • No statistically significant association was found for primary or secondary recurrent abortions.

Conclusions:

  • Current evidence does not support a link between prothrombin G20210A mutation and recurrent miscarriages.
  • The observed odds ratios did not reach statistical significance.
  • Further investigation may be warranted to definitively rule out any association.