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17:16
Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
Published on: December 10, 2010
Drug delivery system to control infectious diseases
Yoko Shoji1, Jingoro Shimada, Yutaka Mizushima
1Higher Dimension Research, Inc., St. Marianna University School of Medicine, St. Paul, MN 55125, USA. YokoShoji@aol.com
Current Pharmaceutical Design
|June 19, 2002
Summary
Genetic medicine offers a promising approach to combat viral infections by targeting viral genes. Advances in genetic medicine and efficient drug delivery systems (DDS) are crucial for developing effective antiviral therapies.
Area of Science:
- Virology
- Molecular Biology
- Genetics
Background:
- Viral replication is confined to host cells, making targeted therapies challenging.
- Genetic medicine, including antisense DNA, offers selective toxicity against viral infections.
- The development of antiviral genetic medicine has progressed significantly, with the first antisense DNA now available.
Purpose of the Study:
- To explore genetic medicine as a strategy for combating viral replication.
- To discuss target molecules for antiviral agents based on viral genome sequences.
- To highlight the need for efficient drug delivery systems (DDS) in antiviral therapy.
Main Methods:
- Review of genetic medicine approaches (antisense DNA, ribozyme, aptamer, triplex, gene therapy).
- Analysis of viral life cycles and genome sequencing for identifying therapeutic targets.
- Discussion of drug delivery systems (DDS) for targeted antiviral agent delivery.
Main Results:
- Genetic medicine provides sequence-specific targeting of viral replication.
- Deciphering viral genomes enables the design of novel genetic antiviral agents.
- Efficient DDS are essential for the clinical success of genetic antiviral therapies.
Conclusions:
- Genetic medicine represents a significant advancement in developing targeted antiviral treatments.
- Understanding viral tropism and life cycles is key to identifying molecular targets.
- Further research into DDS is critical for realizing the full potential of genetic antiviral therapies.
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