Related Experiment Video

Updated: Jun 23, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

The prognostic value of pre-procedural plasma C-reactive protein in patients undergoing elective coronary angioplasty

R J de Winter1, G S Heyde, K T Koch

  • 1Department of Cardiology, Academic Medical Center, University of Amsterdam, The Netherlands.

European Heart Journal
|June 19, 2002
PubMed

Insights

Elevated C-reactive protein before coronary angioplasty predicts poor outcomes. Patients with higher CRP levels faced significantly increased risks of death and heart attack within two years.

Area of Science:

  • Cardiology
  • Inflammation Markers
  • Clinical Prognostics

Background:

  • C-reactive protein (CRP) is a key prognostic indicator in coronary artery disease.
  • Pre-procedural CRP levels may inform treatment strategies for patients undergoing elective coronary angioplasty.

Purpose of the Study:

  • To investigate the prognostic value of pre-procedural C-reactive protein levels in patients undergoing elective coronary angioplasty.
  • To determine the association between elevated CRP and subsequent cardiac events.

Main Methods:

  • Measured pre-procedural plasma C-reactive protein in 501 patients with stable coronary artery disease undergoing elective coronary angioplasty.
  • Followed patients for 2 years to assess outcomes including death, myocardial infarction, and urgent revascularization.
  • Utilized survival analysis and logistic regression to identify predictors of event-free survival.

Main Results:

  • Increased pre-procedural CRP (>3 mg/L) was observed in 45% of patients.
  • Patients with elevated CRP had a significantly higher incidence of death or myocardial infarction (10.6% vs 2.9%) within 2 years (RR 3.9).
  • Elevated CRP was an independent predictor of adverse cardiac events (RR 2.54).

Conclusions:

  • Pre-procedural C-reactive protein is a powerful independent prognostic indicator for cardiac events after elective coronary angioplasty.
  • Elevated CRP suggests that pre-procedural systemic inflammation significantly impacts long-term clinical outcomes.
  • These findings highlight the importance of assessing inflammation status before angioplasty.
Abstract

More Related Videos

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function10:28

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function

Published on: March 15, 2022

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...