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Tissue changes adjacent to titanium plates in patients
Richard J Langford1, John W Frame
1University Hospital Birmingham NHS Trust, Birmingham, UK. langfordnorton@hotmail.com
Summary
Titanium miniplates used in maxillofacial surgery appear well tolerated long-term. Histomorphological analysis revealed fibrosis and particulate titanium debris in adjacent soft tissues, with no significant inflammatory response observed.
Area of Science:
- Maxillofacial Surgery
- Biomaterials Science
- Histopathology
Background:
- Titanium miniplates are standard for osteosynthesis in maxillofacial surgery.
- Long-term effects of retained titanium in human tissues are not fully understood.
Purpose of the Study:
- To histomorphologically evaluate soft tissues adjacent to titanium maxillofacial miniplates.
- To characterize pigmented, particulate debris found in these tissues.
Main Methods:
- Analysis of 35 soft tissue specimens adjacent to titanium miniplates (1 month to 13 years in situ).
- Histopathological examination using light, scanning electron, and transmission electron microscopy.
- Energy dispersive X-ray analysis (EDX) for elemental composition of debris.
Main Results:
- All specimens exhibited fibrosis.
- Pigmented debris, identified as titanium by EDX, was present in 70% of samples.
- Debris was primarily extracellular, with minimal associated inflammation or giant cell reaction.
Conclusions:
- Titanium miniplates demonstrate good biocompatibility in maxillofacial tissues for up to 13 years.
- Observed fibrosis and particulate debris do not elicit significant adverse tissue reactions.