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Updated: Sep 30, 2026

Detection of Horizontal Gene Transfer Mediated by Natural Conjugative Plasmids in E. coli
Published on: March 24, 2023
Novel plasmid-encoded class C beta-lactamase (MOX-2) in Klebsiella pneumoniae from Greece
Laurent Raskine1, Isabelle Borrel, Guilène Barnaud
1Service de Bacteriologie-Virologie, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, 75475 Paris Cedex 10, France. laurent.raskine@lrb.ap-hop-paris.fr
Abstract:
Klebsiella pneumoniae KOL, a clinical strain resistant to various beta-lactams, was isolated from the stools of a patient from Greece. This strain harbored a new pI 9.1 plasmid-mediated AmpC beta-lactamase with unusually high levels of hydrolytic activity for cefoxitin and cefotetan that we named MOX-2. Sequencing of bla(MOX-2) revealed 93.2, 92.9, 92.7, and 73.1% identities with the deduced amino acid sequences of CMY-8, MOX-1, CMY-1, and the AmpC beta-lactamase of Aeromonas sobria, respectively.
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