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APRIL modulates B and T cell immunity.

Jens V Stein1, Marta López-Fraga, Fernando A Elustondo

  • 1Department of Immunology and Oncology, Centro Nacional de Biotecnología, Madrid, Spain.

The Journal of Clinical Investigation
|June 19, 2002
PubMed
Summary
This summary is machine-generated.

The study shows that APRIL, a TNF-like ligand, enhances T cell survival and influences B cell responses. This suggests APRIL plays a role in immune responses involving both T cells and B cells.

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Area of Science:

  • Immunology
  • Molecular Biology

Background:

  • Tumor necrosis factor (TNF)-like ligands APRIL and BLyS bind T cell activation domain-1 (TACI) and B-cell maturation antigen (BCMA).
  • BLyS is crucial for B cell homeostasis and autoimmunity, while APRIL's role is less understood.
  • T cell activation increases APRIL mRNA, suggesting a role in T cell function.

Purpose of the Study:

  • To investigate the biological role of APRIL in T and B cell responses.
  • To determine APRIL's impact on T cell survival and humoral immunity.

Main Methods:

  • Generated transgenic mice expressing APRIL in T cells.
  • Assessed T cell survival in vitro and in vivo.
  • Analyzed humoral immune responses to T cell-dependent and T cell-independent antigens.

Main Results:

  • Transgenic T cells exhibited enhanced survival in vitro and in vivo, correlating with increased Bcl-2 levels.
  • APRIL influenced IgM but not IgG responses to T cell-dependent antigens.
  • T cell-independent type 2 (TI-2) humoral responses were enhanced in APRIL transgenic mice, suggesting a role for APRIL/TACI interactions.

Conclusions:

  • APRIL is involved in the induction and maintenance of T and B cell responses.
  • APRIL enhances T cell survival and modulates specific B cell antibody production pathways.