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Enhanced chemosensitivity after intermittent hypoxic exposure does not affect exercise ventilation at sea level
Keisho Katayama1, Yasutake Sato, Norihiro Shima
1Research Center of Health, Physical Fitness and Sports, Nagoya University, Japan. katayama@htc.nagoya-u.ac.jp
European Journal of Applied Physiology
|June 19, 2002
Summary
Short-term intermittent hypoxic exposure increased resting hypoxic ventilatory response and hypercapnic ventilatory response. However, these changes did not significantly affect exercise ventilation at sea level.
Area of Science:
- Exercise Physiology
- Respiratory Physiology
- Altitude Physiology
Background:
- Intermittent hypoxic exposure is used to acclimatize to high altitudes.
- The effects of short-term hypoxic exposure on exercise ventilation and chemosensitivity are not fully understood.
Purpose of the Study:
- To investigate the impact of one week of intermittent hypoxic exposure on ventilatory response during exercise.
- To determine if hypoxic exposure alters hypoxic ventilatory response (HVR) and hypercapnic ventilatory response (HCVRSB).
Main Methods:
- Subjects underwent daily exposure to simulated altitude (4,500 m) for 7 days.
- Ventilatory response to exercise, HVR, and HCVRSB were measured before and after the exposure period.
- A control group was used for comparison.
Main Results:
- The hypoxic group showed a significant increase in resting HVR (P<0.05) after exposure.
- HCVRSB showed a non-significant increase (P=0.07) in the hypoxic group.
- No significant changes in exercise ventilation (V(E)) were observed in either group.
Conclusions:
- Short-term intermittent hypoxia can enhance resting chemosensitivity.
- These chemosensitivity changes do not appear to significantly alter sea-level exercise ventilation.