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Proteolytic enzyme sensitivity and decrease in respiratory function (a 10-year follow-up).

Ozkan Kizkin1, Gamze Turker Suleyman, S Hacievliyagil

  • 1Department of Pulmonary Diseases, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey. okizkin@inonu.edu.tr

International Archives of Occupational and Environmental Health
|June 19, 2002
PubMed
Summary
This summary is machine-generated.

Detergent enzyme sensitivity significantly reduces respiratory function, specifically forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1). This decline occurs independently of occupational asthma and smoking in enzyme-sensitive workers.

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Area of Science:

  • Occupational Health
  • Pulmonary Medicine
  • Industrial Toxicology

Background:

  • Occupational asthma and sensitivity to proteolytic enzymes in detergent manufacturing are recognized health concerns.
  • Proteolytic enzymes in detergents can trigger respiratory issues in exposed workers.

Purpose of the Study:

  • To investigate the impact of enzyme sensitivity on respiratory function in detergent industry workers.
  • To differentiate the effects of enzyme sensitivity from occupational asthma and smoking on lung function.

Main Methods:

  • Sixty-five detergent industry workers were grouped based on prick-test results for enzymes (Lipolase, Savinase).
  • Respiratory function tests (forced vital capacity - FVC, forced expiratory volume in 1 second - FEV1) over 10 years were analyzed.
  • Statistical analysis included Mann-Whitney U and Fischer Exact chi-square tests.

Main Results:

  • Enzyme-sensitive workers (Group I) showed a significantly greater annual decline in FVC (64.1 ml) and FEV1 (58.7 ml) compared to enzyme-negative workers (Group II).
  • This significant decline (P < 0.001) was also observed in non-smoking enzyme-sensitive workers (Group Ia) versus non-smoking enzyme-negative workers (Group IIa).
  • Smoker status, cigarette burden, age, and work duration were similar across comparable groups.

Conclusions:

  • Enzyme sensitivity, independent of occupational asthma and smoking, is linked to significantly reduced respiratory function (FVC and FEV1).
  • The study suggests that proteolytic enzyme sensitivity is a key factor in the observed decline in lung function among detergent workers.