Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Multiple sclerosis. Therapeutic nihilism is the wrong approach here].

R Voltz1, N Goebels, S Jarius

  • 1Institut für Klin. Neuroimmunologie, Klinikum Grosshadern der LMU München.

MMW Fortschritte Der Medizin
|June 20, 2002
PubMed
Summary

High-dose methylprednisolone treats acute multiple sclerosis relapses. Early interferon beta therapy significantly reduces relapse frequency and delays subsequent events for improved quality of life.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An autoantibody signature predictive for multiple sclerosis: evidence at the protein level and association with histopathological lesion types.

Journal of neurology·2026
Same author

Improving the sensitivity of myelin oligodendrocyte glycoprotein-antibody testing: exclusive or predominant MOG-IgG3 seropositivity-a potential diagnostic pitfall in patients with MOG-EM/MOGAD.

Journal of neurology·2024
Same author

Newly emerging type B insulin resistance (TBIR) during treatment with eculizumab for AQP4-IgG-positive neuromyelitis optica spectrum disorder (NMOSD): fatal outcome.

Journal of neurology·2023
Same author

[Proposal for participation in intensive care and emergency medicine studies for patients unable to give informed consent (Cologne Model)].

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2023
Same author

MOG encephalomyelitis after vaccination against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2): case report and comprehensive review of the literature.

Journal of neurology·2022
Same author

National strategy for palliative care of severely ill and dying people and their relatives in pandemics (PallPan) in Germany - study protocol of a mixed-methods project.

BMC palliative care·2022

Area of Science:

  • Neurology
  • Immunology

Context:

  • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • Acute relapses are a hallmark of MS, significantly impacting patient disability and quality of life.

Purpose:

  • To outline current therapeutic strategies for managing acute relapses and preventing future episodes in multiple sclerosis.
  • To highlight the efficacy of early immunomodulatory treatment in altering disease progression.

Summary:

  • Intravenous high-dose methylprednisolone is the standard for acute MS relapses.
  • Prophylactic options include interferon beta, glatiramer acetate, immunoglobulins, and azathioprine.
  • Interferon beta, when initiated early after the first relapse, reduces relapse frequency by approximately one-third and delays the second relapse.

Related Experiment Videos

Impact:

  • Early intervention with therapies like interferon beta can significantly modify MS disease course.
  • Symptomatic treatments can improve the quality of life for MS patients.
  • An interdisciplinary team approach is crucial for optimal patient management.