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Tooth eruption into the newly generated bone induced by recombinant human bone morphogenetic protein-2
Atsushi Kitamura1, Nobuyoshi Motohashi, Tatsuo Kawamoto
1Maxillofacial Orthognathics, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. a-kitamura.mort@tmd.ac.jp
Summary
Recombinant human bone morphogenetic protein-2 (rhBMP-2) influences tooth eruption into new bone. Lower doses promote eruption, while higher doses cause teeth to erupt around the bone site, indicating a dose-dependent effect.
Area of Science:
- Oral surgery
- Regenerative medicine
- Biomaterials science
Background:
- Bone morphogenetic proteins are crucial for bone regeneration.
- Understanding their effect on tooth eruption is vital for dental applications.
Purpose of the Study:
- To investigate tooth eruption patterns in newly formed bone induced by recombinant human bone morphogenetic protein-2 (rhBMP-2).
Main Methods:
- rhBMP-2 was implanted into alveolar bone defects in beagle dogs.
- Tooth eruption and bone mineral density (BMD) were assessed radiographically and histologically.
- Control groups included non-resected and resected-only sites.
Main Results:
- The 5 microgram/100 microL rhBMP-2 group showed normal eruption and bone density similar to controls.
- The 10 microgram/100 microL rhBMP-2 group exhibited enhanced osteoinduction and higher BMD.
- In the higher dose group, the third incisor erupted mesially, avoiding the treated area.
Conclusions:
- Tooth eruption into rhBMP-2 induced bone is dose-dependent.
- Optimal rhBMP-2 dosage is critical for predictable clinical outcomes in bone regeneration and tooth eruption.