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Related Experiment Video

Updated: Jul 15, 2026

Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions

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Published on: April 18, 2015

Palmar filiform hyperkeratosis (FH) associated with underlying pathology?

R K Mehta¹, R B Mallett, C Green

¹Department of Dermatology, Addenbrooke's Hospital, Oxford, UK. rokmehta@netscapeonline.co.uk

Clinical and Experimental Dermatology

|June 20, 2002

Summary

Filiform hyperkeratosis presents as spiny palm growths, potentially linked to malignancy or myelofibrosis. Thorough investigation is crucial for affected patients due to associated health risks.

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Area of Science:

Dermatology
Oncology
Hematology

Background:

Palmar filiform hyperkeratosis is a rare skin condition.
It presents as multiple thin, spiny keratotic projections on the palms.
Previous reports suggest an association with underlying malignancy.

Observation:

This study details two patients with palmar filiform hyperkeratosis.
One patient exhibited myelofibrosis, a novel association.
A second patient presented with filiform hyperkeratoses on palms and soles without an identified underlying disorder.

Findings:

Filiform hyperkeratosis can manifest with or without associated systemic conditions.
Myelofibrosis represents a newly identified potential comorbidity.
The risk of underlying malignancy necessitates comprehensive patient evaluation.

Implications:

Patients with filiform hyperkeratosis require thorough medical investigation.
Early detection of associated malignancies or hematological disorders is critical.
This condition highlights the importance of a multidisciplinary approach in diagnosis and management.