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Updated: Jul 15, 2026
08:59
Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions
Published on: April 18, 2015
Palmar filiform hyperkeratosis (FH) associated with underlying pathology?
R K Mehta1, R B Mallett, C Green
1Department of Dermatology, Addenbrooke's Hospital, Oxford, UK. rokmehta@netscapeonline.co.uk
Clinical and Experimental Dermatology
|June 20, 2002
Summary
Filiform hyperkeratosis presents as spiny palm growths, potentially linked to malignancy or myelofibrosis. Thorough investigation is crucial for affected patients due to associated health risks.
Area of Science:
- Dermatology
- Oncology
- Hematology
Background:
- Palmar filiform hyperkeratosis is a rare skin condition.
- It presents as multiple thin, spiny keratotic projections on the palms.
- Previous reports suggest an association with underlying malignancy.
Observation:
- This study details two patients with palmar filiform hyperkeratosis.
- One patient exhibited myelofibrosis, a novel association.
- A second patient presented with filiform hyperkeratoses on palms and soles without an identified underlying disorder.
Findings:
- Filiform hyperkeratosis can manifest with or without associated systemic conditions.
- Myelofibrosis represents a newly identified potential comorbidity.
- The risk of underlying malignancy necessitates comprehensive patient evaluation.
Implications:
- Patients with filiform hyperkeratosis require thorough medical investigation.
- Early detection of associated malignancies or hematological disorders is critical.
- This condition highlights the importance of a multidisciplinary approach in diagnosis and management.
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