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Updated: Sep 30, 2026
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
A new computerized methodology to analyse tumour site in relation to phenotypic traits and epidemiological
P Gillgren1, G Brattström, E Djureen Mårtensson
1Department of Surgery, Stockholm Söder Hospital, SE-118 83 Stockholm, Sweden. peter.gillgren@kirurg.sos.sll.se
Background:
While sunlight is important in the aetiology of cutaneous malignant melanoma (CMM), the relationship between skin areas receiving intermittent or chronic sun exposure and the development of CMM has not been fully explored. There is a requirement for an improved method for more detailed site mapping and for analysis of tumour density in different areas of the skin in relation to the type of sun exposure, phenotypic traits and prognosis of patients with CMM.
Objectives:
To describe and demonstrate the use of EssDoll, a new computerized method to map and analyse tumour sites.
Methods:
We have used the new software to analyse data on 2517 patients with 2608 primary CMMs.
Results:
The results obtained were consistent with previous data on the distribution of CMM in men and women. The distribution of CMM on the back was uneven, with the density on the upper back being twice that on the lower back.
Conclusions:
The new methodology allows a more accurate mapping and analysis of skin tumour site, including determination of tumour density. This improves the possibility of analysing tumour site in relation to aetiological, phenotypic and prognostic parameters.
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