Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

"Tissue" transglutaminase in AIDS.

Alessandra Amendola1, Laszlo Fesus, Mauro Piacentini

  • 1I.N.M.I. L. Spallanzani, I.R.C.C.S., Rome, Italy.

Journal of Immunological Methods
|June 20, 2002
PubMed
Summary

Tissue transglutaminase (tTG) is expressed in cells undergoing apoptosis, a key process in development and disease. Its induction in immune cells and detection in plasma may serve as markers for monitoring HIV progression.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characterization of myofiber degeneration by assessment of ER-stress biomarkers.

Methods in cell biology·2026
Same author

Cell death detection in iPSC-derived cortical neurons as model of neurodegeneration.

Methods in cell biology·2026
Same author

Transglutaminase 2 regulates innate immunity: mechanisms and therapeutic implications.

Oncoimmunology·2026
Same author

Methodological guidelines for P2X receptor assays and data interpretation.

Cell death & disease·2026
Same author

Atypical HIV-1 Viremia Persistently Detected Exclusively Through the Pol Target by a Dual-Target (Pol and LTR) Assay: A Case Report About a New Diagnostic Challenge.

International journal of molecular sciences·2026
Same author

Transferrin receptor 1-mediated iron uptake supports thermogenic activation in human cervical-derived adipocytes.

FEBS letters·2026

Area of Science:

  • Cell Biology
  • Immunology
  • Biochemistry

Background:

  • Apoptosis, or programmed cell death, is crucial for multicellular organism development and homeostasis.
  • Viral infections can induce host cell apoptosis, influencing viral pathogenesis.
  • Tissue transglutaminase (tTG) has been identified as a significant factor in cell death pathways.

Purpose of the Study:

  • To review studies on the expression and role of tTG in apoptotic cells.
  • To emphasize tTG's role in HIV-associated immune system apoptosis.
  • To propose tTG as a potential marker for monitoring HIV disease progression.

Main Methods:

  • Review of recent studies on tTG expression in apoptosis.
  • Analysis of tTG's role in HIV-related immune cell death.

Related Experiment Videos

  • Investigation of epsilon(gamma-glutamyl)lysine as a plasma biomarker.

    • Main Results:

    • tTG is specifically expressed in cells undergoing apoptosis during development and in various pathological conditions.
    • tTG expression is implicated in the cell death pathways of HIV-infected immune cells.
    • The isodipeptide epsilon(gamma-glutamyl)lysine is detectable in the plasma of individuals.

    Conclusions:

    • tTG gene induction in immune cells is a marker of apoptosis.
    • Plasma detection of epsilon(gamma-glutamyl)lysine may also indicate apoptosis.
    • These markers could potentially monitor disease progression in HIV-infected individuals.