Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immune dysregulation in atopic dermatitis.

J D Sinke1, V P M G Rutten, T Willemse

  • 1Department of Clinical Science of Companion Animals, Utrecht University, The Netherlands.

Veterinary Immunology and Immunopathology
|June 20, 2002
PubMed
Summary

Atopic dermatitis (AD) involves complex immune responses in both humans and dogs. Comparing these immunological events aids in understanding canine AD and developing treatments for both species.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Calf and dam characteristics and calf transport age affect immunoglobulin titers and hematological parameters of veal calves.

Journal of dairy science·2021
Same author

Differences between Staphylococcus aureus lineages isolated from ovine and caprine mastitis but not between isolates from clinical or subclinical mastitis.

Journal of dairy science·2019
Same author

Characterization of Staphylococcus aureus isolated from milk samples of dairy cows in small holder farms of North-Western Ethiopia.

BMC veterinary research·2018
Same author

Cross reactive immune responses in cattle arising from exposure to Mycobacterium bovis and non-tuberculous mycobacteria.

Preventive veterinary medicine·2018
Same author

Prevalence of bovine tuberculosis in cattle, goats, and camels of traditional livestock raising communities in Eritrea.

BMC veterinary research·2018
Same author

Immune response profiles of calves following vaccination with live BCG and inactivated Mycobacterium bovis vaccine candidates.

PloS one·2017

Area of Science:

  • Immunology
  • Veterinary Dermatology
  • Comparative Pathology

Background:

  • Atopic dermatitis (AD) is a chronic inflammatory skin condition affecting humans and dogs.
  • AD shares comparable clinical manifestations and immunological features across species.
  • Understanding shared pathogenesis is crucial for developing effective immunomodulatory strategies.

Purpose of the Study:

  • To summarize and compare immunological events in human and canine atopic dermatitis.
  • To explore the role of Th2 and Th1 immune responses in AD pathogenesis.
  • To evaluate the utility of comparative studies for advancing AD treatment.

Main Methods:

  • Review and comparison of existing literature on immunological events in human and canine AD.
  • Analysis of data from spontaneous and experimentally induced lesions (atopy patch test).

Related Experiment Videos

  • Focus on temporal changes in immune cell activity and cytokine profiles.

    • Main Results:

    • Both allergen-specific and non-specific mechanisms contribute to AD development.
    • Initial lesions are linked to Th2-type cells, potentially influenced by local factors.
    • Chronic lesions may exhibit a shift towards Th1-type responses, involving IL-12.

    Conclusions:

    • Comparative immunological studies provide valuable insights into canine AD.
    • Understanding species-specific immune responses can guide the development of targeted therapies.
    • Immunomodulatory strategies for human AD may have relevance for canine AD treatment.